Jurgen Klopp’s side trails Barcelona 3-0 after yet another Lionel Messi masterclass gave the Catalans what most people expect to be an insurmountable lead.
If the Reds are to pull off the impossible and reach the final in Madrid, they will need to do so without two-thirds of its attacking triumvirate.
Klopp is also without Naby Kieta, who injured his groin in the first leg and is out for the rest of the season.
Liverpool’s lack of attacking options could see 19-year-old youngster Rhian Brewster make his debut for Liverpool.
“He’s ready,” Klopp told reporters ahead of Tuesday’s game. “There is a big chance. It’s nearly sure. It’s guaranteed.”
Barcelona, which has already won La Liga, is suffering from no such injury worries and is on the brink of a first Champions League final since the 2015 victory over Juventus.
Much has changed since then, with Neymar, Andres Iniesta, Xavi, Javier Mascherano and Dani Alves all leaving the club and Arturo Vidal switching allegiances via Bayern Munich.
If Liverpool is not able to overturn the deficit, then Klopp has urged his side to “fail in the most beautiful way.”